MSDS-Europe – Compass for Chemical Safety – 2026 Chemical Compliance Calendar (CLP / SDS / PCN-UFI)
For the European chemical industry and the economic operators participating in the chemical supply chain, 2026 will be one of the most complex periods of the past decade from a regulatory compliance perspective.
The purpose of this article is to help businesses working with chemicals and mixtures (manufacturers, importers, distributors, webshops) review the most important annual compliance tasks on a yearly timeline: Safety Data Sheets (SDS), CLP labelling, PCN notifications and UFI, supplier documentation and online sales.
Substance: a single chemical element or compound (e.g., ethanol).
Mixture: a solution composed of two or more substances (e.g., cleaning agent, paint, adhesive).
CLP Regulation (Regulation (EC) No 1272/2008): the EU framework for the classification, labelling and packaging of substances and mixtures (hazard classes, pictograms, hazard statements (H statements), precautionary statements (P statements), EUH statements, etc.).
Safety Data Sheet (SDS): a standardised, structured document prepared for users, providing information on the hazards of a substance/mixture and on safe handling, storage and disposal; it follows a 16-section format.
PCN (Poison Centre Notification): a notification of the composition and toxicological information of hazardous mixtures to poison centres, in the harmonised format set out in Annex VIII to the CLP Regulation.
UFI (Unique Formula Identifier): a 16-character code used to link the PCN notification and the label (for mixtures).
New CLP hazard classes (Commission Delegated Regulation (EU) 2023/707): including endocrine disruptors (human health/environment), PBT/vPvB, PMT/vPvM – these introduce new classification and labelling considerations and, in some cases, new EUH statements.
1. New hazard classes – mixtures (newly placed on the market)
1 May 2026: the new hazard classes apply to mixtures placed on the market from 1 May 2026.
2. New hazard classes – substances (already on the market)
1 November 2026: the transitional period for substances already placed on the market ends; from this date, compliance with the new hazard classes is mandatory.
3. PCN – the harmonised format is now a baseline expectation
From 1 January 2025, PCN notifications for all hazardous mixtures placed on the EU market must be submitted in the harmonised format; in 2026, the focus is typically on quality, updates and change management.
4. CLP online sales/advertising – deadline postponed
It is important to note that, for the CLP “online” rules, the previously communicated application dates for 2026–2027 have been postponed to 1 January 2028 (including requirements for advertisements and distance-selling offers).
Therefore, the right approach in 2026 is data and interface preparation, not a “last-minute” switchover.
5. PFAS (per- and polyfluoroalkyl substances) – two parallel tracks in 2026
The European Commission recognised that the previous classification framework did not adequately address long-term risks such as endocrine disruption or environmental mobility.
As a result, Commission Delegated Regulation (EU) 2023/707 was adopted, which introduced six new hazard classes into the EU legal framework.
The introduction of the new classes is not merely an administrative change – it is also a scientific paradigm shift.
For identifying endocrine-disrupting properties, the legislator relied on the World Health Organization (WHO) definition. A substance is considered an endocrine disruptor if endocrine activity is demonstrated, an adverse effect is observed in an intact organism, its progeny or (sub)populations, and there is a biologically plausible causal relationship between the two.
The persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB) and persistent, mobile and toxic (PMT) / very persistent and very mobile (vPvM) hazard classes aim to address environmental risks.
While PBT substances pose a hazard due to their accumulation in the food chain, PMT substances, because of their mobility, can enter the water cycle and travel far from the source, reaching areas where their concentrations become difficult to control. This property is particularly critical for the protection of drinking water resources.
The table below summarises the new classes and their associated codes:
| Hazard class name | Category | Abbreviation | Related EUH statement |
|---|---|---|---|
| Endocrine disruptor (human health) | Category 1 | ED HH 1 | EUH380 |
| Endocrine disruptor (human health) | Category 2 | ED HH 2 | EUH381 |
| Endocrine disruptor (environment) | Category 1 | ED ENV 1 | EUH430 |
| Endocrine disruptor (environment) | Category 2 | ED ENV 2 | EUH431 |
| Persistent, bioaccumulative and toxic | – | PBT | EUH440 |
| Very persistent and very bioaccumulative | – | vPvB | EUH441 |
| Persistent, mobile and toxic | – | PMT | EUH450 |
| Very persistent and very mobile | – | vPvM | EUH451 |
For mixtures, the date of 1 May 2026 is a clear dividing line: any mixture placed on the EU market from that date must comply with the new classification rules.
For substances, the deadline of 1 November 2026 is the final date for so-called “legacy” substances already on the market. After that, no substance may remain on the market if its label and Safety Data Sheet do not include the relevant information required under the new hazard classes.
The table below illustrates the logic of the process:
| Product type | Market status | Mandatory application starts |
|---|---|---|
| Substance | New (placed on the market) | 1 May 2025 |
| Substance | Already on the market | 1 November 2026 |
| Mixture | New (placed on the market) | 1 May 2026 |
| Mixture | Already on the market | 1 May 2028 |
The table highlights a critical strategic point: although mixtures already on the market are granted a grace period until 2028, the November 2026 switchover for raw materials (substances) will force mixture manufacturers to review their formulations by the end of 2026, because SDS updates will start arriving from suppliers in an avalanche.
The revision of the CLP Regulation and the “Stop the Clock” mechanism.
Regulation (EU) 2024/2865 is the most comprehensive textual amendment to the CLP Regulation to date, focusing on digitalisation, online commerce and administrative simplification.
However, due to concerns raised by industry stakeholders, the European Parliament and the Council adopted Regulation (EU) 2025/2439, commonly referred to in the industry as the “Stop the Clock” Regulation.
Under the amendment adopted at the end of 2025, the deadlines for several key obligations were moved to 1 January 2028.
Deferrals to 2028 cover the following areas:
This deferral gives businesses breathing space in 2026; however, the legislator emphasises that it does not mean preparations should stop. 2026 should be the year of populating structured data (PIM systems).
Annex XVII to the REACH Regulation contains restrictions for certain substances and/or mixtures.
In 2026, two areas reach a turning point that affects almost every sector: PFAS and cyclic siloxanes.
PFAS firefighting foams and the obligation to have management plans
Regulation (EU) 2025/1988 introduced entry 82 into Annex XVII to REACH, restricting the use of per- and polyfluoroalkyl substances (PFAS) in firefighting foams. Due to their extraordinary stability, PFAS are often referred to as “forever chemicals” and can cause irreversible damage once released into the environment.
Key PFAS-related deadlines in 2026:
The PFAS Management Plan must include:
This documentation must be retained for at least 15 years and must be presented upon request by the competent authority (for example, disaster management or environmental authorities).
Phase-out of cyclic siloxanes (D4, D5, D6)
Regulation (EU) 2024/1328 amended entry 70 of Annex XVII to REACH, tightening restrictions on the use of cyclic siloxanes (D4, D5, D6). These substances are widely used in the cosmetics industry, dry cleaning and many industrial technologies.
Under the restriction, after 6 June 2026, octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6) may not be placed on the market on their own or in mixtures at concentrations above 0.1% by weight (certain exemptions are specified in the Regulation).
This deadline particularly affects cosmetic products, except for rinse-off products, which were already subject to earlier restrictions. It is also a critical date for the dry-cleaning sector, since the use of solvents containing these substances will be prohibited from that point.
While the label format has been postponed, several technical and procedural rules become mandatory from 1 July 2026 under Regulation (EU) 2024/2865.
Objective: the company should have a clear view of which products require which documents and obligations, and where gaps exist.
Recommended steps:
Objective: ensure that the classification and labelling of mixtures placed on the market from 1 May 2026 are carried out with the new hazard classes taken into account. By this point, mixture manufacturers should already have reclassification data for their raw materials.
Recommended steps:
Label versioning and approval: an internal workflow (who decides, who approves, how versions are archived).
Objective: compliance should not be a campaign, but business-as-usual operations.
Recommended steps:
Objective: ensure that the classification and labelling of affected substances is in order by the 1 November 2026 deadline; and ensure that the start of PFAS applicability in 2026 does not go unnoticed.
Recommended steps:
“PFAS Management Plan”: by 23 October, the firefighting foam management plan must be completed and signed, and kept on file in the site’s document archive.
In the field of chemical safety, 2026 is not merely another administrative milestone, but part of a profound structural transformation.
Economic operators must recognise that, alongside traditional acute hazards (corrosivity, flammability), the regulatory focus now also includes chronic and environmental risks (endocrine disruption, environmental mobility).
Main strategic points for 2026:
The key to successful compliance in 2026 is applying the “Compliance by Design” principle: every new product development and market launch must be assessed from the outset in light of the new CLP hazard classes and the REACH restrictions (siloxanes, PFAS).
This proactive approach not only prevents regulatory fines but also provides a competitive advantage in the European market that prioritises sustainability.
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